Our projects push the frontier of optimisation to meet the modeling and computational requirements underlying these challenges. We develop the decision support to prepare, mitigate, respond, and recover from natural disasters and security threats. We study how to plan and operate the smart grid in order to integrate renewable energies and support large-scale distributed generation. We explore how to build the next generation of logistics and supply-chain software, striving toward holistic optimisation in multi-modal environments. We collaborate with biologists and social scientists to elucidate and regulate large-scale biological and social processes.